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    Emdogain Therapy- Regeneration of gum tissues
    September 28th, 2008

    CALL NOW  +44 1580 762323


    Biora_enacnce_pic.JPG (95232 bytes)

    Detail of the period when the root sheath cells (blue) secrete enamel matrix proteins. Following formation of the protein matrix on the surface of the mineralizing dentin, cementoblasts (Red) start producing cementum (Light blue) which anchors collagen fibers.

    The Next Generation

    In the mid 1980’s, a revolutionary breakthrough in the basic biology of tooth development took place at the Karolinska Institute’s department of Oral Pathology in Stockholm. The discovery revealed a native complex of enamel matrix proteins and the key if not crucial , role they play in the development of tooth-supporting tissues. These enamel related proteins mediate the formation of acellular cementum on the root of the developing tooth, providing a foundation for all of the necessary tissues associated with a functional periodontal attachment.

    This groundbreaking discovery has fueled the development of a new generation in periodontal therapy, and makes the recreation of lost tooth support an attainable goal in the treatment of patients suffering from periodontitis.

    It Begins with a single product… 


    Is an enamel matrix protein that recreates all necessary tissues of true functional attachment in patients presenting with moderate to advanced peridontitis.

    EMDOGAIN represents a completely new way of thinking about the regain of functional tooth support. Designed to be a simple adjunctive product, EMDOGAIN fits naturally into established periodontal treatments. The EMDOGAIN product is packaged in two vials – a vehicle solution and freeze dried enamel matrix proteins (The amelogenin fraction). When mixed, they create a viscous, easy to use, syringable gel that is applied quickly and easily during normal flap surgery.

    biora_bottle.JPG (55895 bytes)

    EMDOGAIN prompts a natural biology-based response in the body.

    EMDOGAIN is resorbed naturally during the normal healing process, leaving only a residue of enamel matrix protein on the debrided root surface. This natural and insoluble surface layer encourages the population of cementum-forming cells from the surrounding tissues.

    The newly created surface also functions as an interface between the tooth and the surrounding tissues, preventing downgrowth of the epithelial tissues.

    In promoting rapid initial healing, EMDOGAIN causes little or no associated  postoperative pain and swelling.

    EMDOGAIN   creates a surface for cementum production

    Experimental studies in a marginal dehiscence  model in primates show that EMDOGAIN creates a suitable surface for the colonization of cementum-forming cells. Two weeks after application, 75% of the dentin surface is covered with such cells. After cementum formation, the periodontal ligament and alveolar bone are then established.

    biora_example1.JPG (45084 bytes)

    EMDOGAIN promotes growth of all periodontal tissues

    • Acellular cementum
    • Functional periodontal tissues
    • Alveolar bone

    The histological picture to the left shows periodontal regeneration in an experimental dehiscence defect in a primate eight weeks after EMDOGAIN treatment.

    A firmly attached acellular cementum (C) with collagen fibers (ARROWS) can be seen extending over to the newly formed alveolar bone (AB).

    The polarized light also shows how the collagenus fibers extend deeply into the newly-formed cementum.

    biora_example2.JPG (28630 bytes)

    A product as safe as it is effective!

    The safety of EMDOGAIN has been completely documented. A thorough toxicology program, including acute and chronic toxicity studies, in vitro mutagenicity studies, reproductive toxicological tests, and several additional toxicology studies has been carried out. The potential for sensitization and other immunological reactions in humans were  also examined. No immunological or allergic reactions were found.

    Clinical documentation for EMDOGAIN has been obtained from series of strictly designed studies involving nearly 300 patients at 15 clinics throughout the US. and Sweden. Patients have been followed for over three years and have shown uniform improvement in EMDOGAIN treated teeth compared to control surgery, by achieving statistical significance for probing pocket reduction, clinical attachment gain and radiographic bone gain.

    biora_graphs.JPG (41704 bytes)
    Each patient had a test site treated with flap surgury and adjunctive EMDOGAIN and a control site (of similar morphology and in the same jaw) treated with an identical surgical procedure that did not include EMODGAIN

    Look at the facts

    • Female
    • 51 years
    • Smoker
    • Generalized adult periodontitis with horizontal & verical bone loss.

    Initial probing pocket depth-10mm

    Clinical Attachment loss – 12mm

    8 months after flap surgery and single application of EMODOGAIN resulting in:

    Probing pocket reduction – 8mm

    Clinical Attachment gain – 7mm

    Radiographic bone gain – 7mm

    Clinical trial results show that EMDOGAIN gains both clinical attachment and bone in 93% of cases. Studies also shows that patients with periodontal pockets (more than 6mm) of the 1-wall and 2-wall type may except to achieve significant alveolar bone regain up to 60-70% defect fill.

    Biora_before_after.JPG (29787 bytes)

    Posted in Dr V J Vadgama | Tags: |

    2 Responses to Emdogain Therapy- Regeneration of gum tissues

    1. Pain and misery says:

      I sure Straumann loves this promotion but the facts are: common side effect of Emdogain are;
      Urticaria, itching skin reaction, gastrointestinal disturbances, urogenital disturbances because it causes protein allergy.

      I had an emdogain implant and it resulted in 3 years of ill health and pain. Will always regret having it.

    2. big regret says:

      Sure is just a straumann promotion. A pack of lies! I had emdogain on one tooth 2 years ago and my health is ruined with constant and extreme urticarial and breathing problems. I have to take antihistamines everyday and only get some relief. I fear I will never recover. Money rules stuff the patient.